Objectives: Venusia Acne facewash is formulated with a synergistic blend of mild surfactants, humectants, and soothing agents to cleanse while maintaining skin hydration. The study evaluated its efficacy and in-use skin tolerance in men and women compared with baseline. Materials and Methods: This single-center, single-arm, non-randomized, interventional study enrolled men and/ or women aged ≥15 years with grade 2–3 acne as per investigator global assessment (IGA) scale. Subjects used Venusia Acne facewash twice daily for 15 days. Skin pH and pore cleansing efficacy were assessed at baseline, 15–20 min post-application, and Day 15, along with representative full-face photographs of select subjects taken at the same time points. Transepidermal water loss (TEWL), acne severity (IGA scale), acne lesion characteristics (3D imaging), and skin tolerance (erythema and edema using modified Draize scale) were evaluated at baseline and Day 15, alongside standardized photographs of acne sites. Consumer feedback was collected on Day 15 through a structured questionnaire. Results: Of 77 enrolled subjects, 74 completed the study. The mean age was 27.99 ± 8.75 years, and 66.2% were female. Among the total study population, 32 subjects with acne grade 2–3 were evaluated for 3D imaging parameters. Skin pH remained stable both immediately after first use and after 15 days, indicating no disruption of skin acidity. From baseline to Day 15, TEWL significantly decreased from 16.42 ± 3.39 to 15.57 ± 3.27 ( p = 0.001), reflecting improved skin barrier function. Mean IGA acne severity scores showed a significant reduction from 2.22 ± 0.42 to 1.88 ± 0.66 ( p = 0.003). 3D imaging showed a slight increase in mean maximum pore depth 15–20 min post-application (0.033 ± 0.010 mm to 0.036 ± 0.011 mm). From baseline to Day 15, significant improvements were observed in mean maximum pore depth and reductions in acne lesion volume, area, and height (all having p = 0.001). Over 95% of subjects agreed or strongly agreed that the face wash was gentle, cleansed effectively, controlled oil, and reported that they liked the product overall. No subjects showed any signs of erythema, oedema, or skin intolerance, and no adverse events were reported throughout the study. Conclusion: Venusia Acne facewash use over 15 days was associated with improvements in acne outcomes and skin barrier function without altering skin pH or causing irritation. The product demonstrated excellent skin tolerance, safety, and user satisfaction, indicating its potential suitability for regular use in individuals with acne-prone skin.
Gala et al. (Wed,) studied this question.