Current tissue adhesives struggle with wet adhesion and phased treatment during coagulation‐healing transitions. Here, we developed a mechano‐adaptive PAA‐NHS/PEI/Fibrin (PNPF) powder adhesive featuring a dual‐network architecture, integrating a polyelectrolyte matrix (PAA‐NHS/PEI) and fibrin network through chemical linkages and thrombin activation, which displayed remodeling ability after fragmentation of the network. Benefitting from the combination of the two networks, PNPF powder adhesive exhibited water‐absorbent self‐gelation capability and bioactive properties, encompassing both procoagulant and prohealing abilities. More concretely, the powder adhesive exhibited ultrafast and robust sealing on biological tissues via interfacial dehydration and interface coupling, with the burst pressure achieving 180.7 mmHg. By integrating its superior coagulation‐enhancing properties, the PNPF powder adhesive demonstrated notably accelerated hemostatic efficacy in both rat tail and liver injury models compared to conventional hemostatic products. Furthermore, the adhesive substantially accelerated posthemostasis tissue repair processes, establishing itself as a viable strategy for advanced wound care management.
Zhang et al. (Wed,) studied this question.