Biomembrane-coated Nanoparticles Targeting circHIF1α Suppress Ovarian Cancer Metastasis and Cisplatin Resistance by Mediating System Xc⁻ Inactivation via SLC7A11/SLC3A2 to Induce Ferroptosis in Cancer Stem Cells

Key Points

• This research aims to investigate how biomembrane-coated nanoparticles can target circHIF1α to reduce ovarian cancer metastasis and overcome cisplatin resistance.
• Utilized nanoparticles coated with biomembranes to target circHIF1α.
• Assessed the role of system Xc⁻ mediated by SLC7A11 and SLC3A2 in inducing ferroptosis in ovarian cancer stem cells.
• Evaluated the impact on cancer metastasis and drug resistance using cisplatin.
• The treatment significantly decreased ovarian cancer metastasis in experimental models.
• Ferroptosis was effectively induced in cancer stem cells, with increased expression of SLC7A11 and SLC3A2 observed.
• The nanoparticles demonstrated an ability to overcome cisplatin resistance in these cancer cells.