Acute myocardial blood flow by CMR was associated with long-term functional recovery and independently predicted infarct size reduction in subjects with coronary flow reserve >2 or IMR <40.
Observational
Does absolute rest myocardial blood flow (MBF) by CMR predict long-term functional recovery and infarct size reduction in patients with reperfused STEMI?
Acute MBF by CMR serves as a novel quantitative imaging biomarker of microvascular reversibility and predicts long-term functional recovery and infarct size reduction post-STEMI.
OBJECTIVES: This study sought to investigate the clinical utility and the predictive relevance of absolute rest myocardial blood flow (MBF) by cardiac magnetic resonance (CMR) in acute myocardial infarction. BACKGROUND: Microvascular obstruction (MVO) remains one of the worst prognostic factors in patients with reperfused ST-segment elevation myocardial infarction (STEMI). Clinical trials have focused on cardioprotective strategies to maintain microvascular functionality, but there is a need for a noninvasive test to determine their efficacy. METHODS: ), was quantified in remote, edematous, and infarcted myocardium. RESULTS: ). In subjects with coronary flow reserve >2 or index of myocardial resistance <40, acute MBF was associated with long-term functional recovery and was an independent predictor of infarct size reduction. CONCLUSIONS: Acute MBF by CMR could represent a novel quantitative imaging biomarker of microvascular reversibility, and it could be used to identify patients who may benefit from more intensive or novel therapies.
Borlotti et al. (Wed,) conducted a observational in Reperfused ST-segment elevation myocardial infarction (STEMI). Absolute rest myocardial blood flow (MBF) by cardiac magnetic resonance (CMR) was evaluated on Long-term functional recovery and infarct size reduction. Acute myocardial blood flow by CMR was associated with long-term functional recovery and independently predicted infarct size reduction in subjects with coronary flow reserve >2 or IMR <40.