Why the study?
Does hemophilia protect against the development of atherosclerosis compared to age-matched controls?
Population
100 individuals: 50 carriers of hemophilia and 50 age-matched control individuals
Comparison
Hemophilia vs Age-matched control individuals with normal…
Design
Case-control
Key result
Carriers of hemophilia had a lower prevalence of at least one atherosclerotic plaque compared to age-matched controls (12.0% vs 30.0%), indicating protection against asymptomatic atherosclerosis.
Authors
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Hemophilia carrier status was associated with fewer plaques; leaves open whether reduced coagulation protects against clinical events and should not yet change practice.
Case-Control (n=100)
Does hemophilia protect against the development of atherosclerosis compared to age-matched controls?
Absolute Event Rate: 12% vs 30%
Hemophilia appears to protect against asymptomatic atherosclerosis, as evidenced by a lower prevalence of atherosclerotic plaques and reduced intima-media thickness.
Bilora et al. (2006) conducted a case-control in Hemophilia and atherosclerosis (n=100). Hemophilia carrier status vs. Age-matched control individuals was evaluated on Presence of at least one atherosclerotic plaque. Carriers of hemophilia had a lower prevalence of at least one atherosclerotic plaque compared to age-matched controls (12.0% vs 30.0%), indicating protection against asymptomatic atherosclerosis.