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Using quantitative PET, the authors studied the binding of 11CPK11195, a marker of activated microglia, in the thalamus of patients with chronic middle cerebral artery infarcts. All patients showed increased 11CPK11195 binding in the ipsilateral thalamus, indicating the activation of microglia in degenerating projection areas remote from the primary lesion. A persistent increase in 11CPK11195 binding suggests active, long-term thalamic microstructural changes after corticothalamic connection damage.
Pappatà et al. (Tue,) studied this question.