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Although D-Limonene can be considered an important component of nature-based stimuli, the physiological effects of olfactory stimulation with D-Limonene have not been completely clarified by scientific studies. The physiological and psychological effects of olfactory stimulation with D-Limonene were studied measuring heart rate variability (HRV), heart rate, and subjective evaluation using a modified semantic differential method; thirteen Japanese female university students (mean age±SD, 21.5±1.0 years) participated in the study. A concentration of 60 μL of D-Limonene was used as olfactory stimulant and room air as control. Subjects were exposed for 90 s while sitting with eyes closed. During D-Limonene inhalation: (1) the high-frequency (HF) value of HRV, a marker of parasympathetic nervous activity that is enhanced in relaxing situations, was significantly higher; (2) the heart rate was significantly lower; and (3) subjects reported feeling significantly more comfortable during D-Limonene administration than control. The results obtained clearly indicate that olfactory stimulation with D-Limonene induced physiological and psychological relaxation, providing important scientific evidence of the health benefits of D-Limonene.
Joung et al. (Wed,) studied this question.