Assessment of apolipoproteinsA1, E, and Insulin Resistance in Iraqi male patients with acute myocardial infarction

Background: Insulin resistance (IR) is a risk factor for ischemic heart disease and myocardial infarction. It often manifests in myocardial infarction and is regarded as an independent predictor of in-hospital mortality, which can provide early risk stratification for recurrent acute coronary events. Objective: The aim of this study was to assess the levels of apolipoproteinsA1, E with IR in Iraqi male patients with acute myocardial infarction (AMI). Patients and Methods: Forty-five male patients with AMI were enrolled in this study. Their age range was 40–55 years and they are compared with 45 healthy male as a control group. All patients with AMI were checked up by a cardiologist in Iraqi Centre for Cardiovascular Diseases/Al-Hariry Hospital/Baghdad. Fasting venous blood samples were collected from all the subjects. Laboratory evaluations consisted of fasting serum glucose (FSG), glycated hemoglobin (HbA1c), serum insulin, and lipid profile. Furthermore, apolipoproteinsA1 and E levels were determined in this study. Results: There was a significant increase in FSG and insulin levels in patients group as compared to the controls. In addition, there was an elevation in HbA1c and homeostasis model assessment for IR in those patients, but they were not significant. There was a significant increase (P = 0.001) in serum total cholesterol, triglyceride, and low-density lipoprotein cholesterol, while there was a significant decrease in serum high-density lipoprotein cholesterol in patients group as compared to the controls. Moreover, there was a significant increase (P = 0.001) in apolipoprotein E, while a significant decrease (P = 0.001) in apolipoproteinsA1in patients group as compared to the controls. Conclusions: Dyslipidemia, along with insulinemia and glycemia, is one of the most significant IR risk factors in the acute and early recovery phases of myocardial infarction.