Fasting serum total homocysteine levels were significantly higher in young adults with a history of ischemic stroke compared to healthy controls (13.03 vs 10.75 micromol/L; P=0.004).
Case-Control (n=394)
No
Are hyperhomocysteinemia and inherited prothrombotic mutations associated with a history of ischemic stroke in young adults?
Moderate hyperhomocysteinemia, but not common prothrombotic gene mutations, is associated with a history of ischemic stroke in young adults.
Absolute Event Rate: 13.03% vs 10.75%
p-value: p=0.004
BACKGROUND AND PURPOSE: The mechanisms of ischemic stroke in young adults are poorly understood. During the last years, several studies suggested a role for genetic factors predisposing to thrombophilia and for moderate hyperhomocysteinemia in this setting. METHODS: We evaluated in 132 consecutive patients (66 males, 66 females; mean+/-SD age, 38.4+/-11.7 years; mean+/-SD age at first event, 34.8+/-10.9 years; range, 6 months to 50 years) referred to our center between January 1997 and December 1999 for a history of young adult ischemic stroke (age at first event, 0.05, chi(2) test). However, when we stratified the whole population according to genotype, fasting serum homocysteine levels were significantly higher in TT patients than in TT controls (25.3+/-36.8 versus 15+/-11.6 micromol/L; P=0.02, t test). Mutations of FV Leiden and of FII G20210A gene are currently reported to be associated with a tendency toward ischemic stroke. Their frequencies were not statistically significantly different between patients and controls in this setting: 7 of 132 (5.3%) versus 17 of 262 (6.5%) for FV Leiden and 10 of 132 (7.6%) versus 16 of 262 (6.1%) for FII G20210A, respectively (all P>0.05, chi(2) test). CONCLUSIONS: In the present cohort of patients, moderate hyperhomocysteinemia is the only variable that helps to identify young adults with a history of ischemic stroke.
Madonna et al. (Tue,) conducted a case-control in Ischemic stroke in young adults (n=394). Prothrombotic genetic mutations and fasting serum total homocysteine levels vs. Apparently healthy subjects was evaluated on Fasting serum total homocysteine levels (micromol/L) (p=0.004). Fasting serum total homocysteine levels were significantly higher in young adults with a history of ischemic stroke compared to healthy controls (13.03 vs 10.75 micromol/L; P=0.004).
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