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Sixty patients with well-established essential hypertension form the basis of this report. These patients were selected from the Hyperten-sion and Nephritis Clinic of the New York University Clinic. A few subjects with radio-logic evidence of uropathology are included, but none who have evidence of glomerular nephritis or other specific renal disease. A major difficulty in a problem such as is con-sidered here is that the investigator cannot readily observe a particular patient pass from health through various stages of the disease, nor yet pass from any stage of the disease back into health. The perturbations of function in essen-tial hypertension are so insidious in onset and
Goldring et al. (Sat,) studied this question.