Heart Age can be accurately estimated from a standard 10-s 12-lead ECG, showing strong agreement with 5-min ECG Heart Age (R2 = 0.94) and a Heart Age Gap that increases markedly with cardiovascular risk and disease.
Cross-Sectional (n=2,771)
Yes
Can explainable advanced measures from a standard 10-s 12-lead ECG accurately predict Bayesian 5-min ECG Heart Age and reflect cardiovascular risk?
Heart Age can be accurately estimated from a standard 10-s 12-lead ECG using transparent, explainable measures, and the gap between Heart Age and chronological age increases significantly with cardiovascular risk and disease.
Effect estimate: R2 = 0.94
p-value: p=<0.001
Abstract Electrocardiographic (ECG) Heart Age conveying cardiovascular risk has been estimated by both Bayesian and artificial intelligence approaches. We hypothesised that explainable measures from the 10-s 12-lead ECG could successfully predict Bayesian 5-min ECG Heart Age. Advanced analysis was performed on ECGs from healthy subjects and patients with cardiovascular risk or proven heart disease. Regression models were used to predict patients’ Bayesian 5-min ECG Heart Ages from their standard, resting 10-s 12-lead ECGs. The difference between 5-min and 10-s ECG Heart Ages were analyzed, as were the differences between 10-s ECG Heart Age and the chronological age (the Heart Age Gap). In total, 2,771 subjects were included (n = 1682 healthy volunteers, n = 305 with cardiovascular risk factors, n = 784 with cardiovascular disease). Overall, 10-s Heart Age showed strong agreement with the 5-min Heart Age (R 2 = 0.94, p < 0.001, mean ± SD bias 0.0 ± 5.1 years). The Heart Age Gap was 0.0 ± 5.7 years in healthy individuals, 7.4 ± 7.3 years in subjects with cardiovascular risk factors ( p < 0.001), and 14.3 ± 9.2 years in patients with cardiovascular disease ( p < 0.001). Heart Age can be accurately estimated from a 10-s 12-lead ECG in a transparent and explainable fashion based on known ECG measures, without deep neural network-type artificial intelligence techniques. The Heart Age Gap increases markedly with cardiovascular risk and disease.
Lindow et al. (Tue,) conducted a cross-sectional in Cardiovascular risk and disease (n=2,771). 10-s 12-lead ECG Heart Age estimation vs. 5-min ECG Heart Age was evaluated on Agreement between 10-s Heart Age and 5-min Heart Age (R2 = 0.94, p=<0.001). Heart Age can be accurately estimated from a standard 10-s 12-lead ECG, showing strong agreement with 5-min ECG Heart Age (R2 = 0.94) and a Heart Age Gap that increases markedly with cardiovascular risk and disease.