A higher plasma atherogenic index was an independent predictor of increased arterial stiffness in healthy Korean men (Q4 vs Q1 OR 2.77) and women (OR 1.83; P trend <0.05).
Cross-Sectional (n=3,468)
Is a higher plasma atherogenic index associated with increased arterial stiffness in healthy adults?
A higher plasma atherogenic index is strongly associated with increased arterial stiffness in healthy adults, suggesting its potential as a simple screening tool for subclinical atherosclerosis.
Effect estimate: OR 2.77 (men Q4), OR 1.83 (women Q4)
p-value: p=<0.05 (P trend)
The plasma atherogenic index (AIP) has been suggested as a useful independent predictor of cardiovascular diseases (CVDs) in high CV risk patients. We investigated the association between AIP and arterial stiffness measured by brachial–ankle pulse wave velocity (baPWV) in healthy adults. A total of 3468 healthy subjects without any metabolic or CV diseases were enrolled. Anthropometric and CV risk factors were measured. The AIP was defined as the base 10 logarithm of the ratio of the concentration of triglycerides to high-density lipoprotein-cholesterol. Subjects were classified into AIP quartiles. There were gradual deteriorations in metabolic parameters and increase in baPWV across the increasing AIP quartiles. In a fully adjusted analysis, compared with Q1 (lowest quartile) group, the odds ratio (95% confidence interval) for increased baPWV was higher in Q2 1.51, Q3 1.64, and Q4 (highest quartile) 2.77 among men, and Q2 1.09, Q3 1.55, and Q4 1.83 among women (all P trend <0 .05). There was a strong association between AIP and baPWV, and a higher AIP was an independent predictor of increased arterial stiffness in healthy Korean men and women. The AIP may be a simple screening tool for subclinical atherosclerosis.
Nam et al. (Sun,) conducted a cross-sectional in Healthy adults (n=3,468). Plasma atherogenic index (AIP) vs. Lowest AIP quartile (Q1) was evaluated on Increased arterial stiffness measured by brachial-ankle pulse wave velocity (baPWV) (OR 2.77 (men Q4), OR 1.83 (women Q4), p=<0.05 (P trend)). A higher plasma atherogenic index was an independent predictor of increased arterial stiffness in healthy Korean men (Q4 vs Q1 OR 2.77) and women (OR 1.83; P trend <0.05).