Highly Potent Adrenal Cortical Steroids: Structure and Biologic Activity

Article1 November 1955HIGHLY POTENT ADRENAL CORTICAL STEROIDS: STRUCTURE AND BIOLOGIC ACTIVITYGEORGE W. THORN, M.D., F.A.C.P., ALBERT E. RENOLD, M.D., WILLIAM I. MORSE, M.D., ALAN GOLDFIEN, M.D., WILLIAM J. REDDY, A.B.GEORGE W. THORN, M.D., F.A.C.P.Search for more papers by this author, ALBERT E. RENOLD, M.D.Search for more papers by this author, WILLIAM I. MORSE, M.D.Search for more papers by this author, ALAN GOLDFIEN, M.D.Search for more papers by this author, WILLIAM J. REDDY, A.B.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-43-5-979 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptSynthetic adrenal steroids possessing biologic activity greater than that of the naturally occurring secretory products of the adrenal cortex are of considerable theoretic importance and, in certain instances, may offer unusual opportunities for hormone therapy. Furthermore, it is of particular interest that the isolation and identification of a very active, naturally occurring sodium-retaining adrenal steroid (aldosterone) should have coincided with the synthesis of derivatives of hydrocortisone possessing physiologic activities manyfold greater than those of any previously known naturally occurring steroid. In 1954 Reichstein announced the identification and crystallization of "aldosterone," a naturally occurring adrenal steroid first described by Simpson and...Bibliography1. SimpsonTaitBush SAJFIE: Secretion of a salt-retaining hormone by the mammalian adrenal cortex, Lancet 2: 226, 1952. CrossrefMedlineGoogle Scholar2. SimpsonTaitWettsteinHehervon EuwSchindlerReichstein SAJFARJOT: Die Konstitution des Aldosterons. Über Bestandteiler der Nebennierenrinde und verwandte Stoffe, Helv. chem. acta 37: 1200, 1954. CrossrefGoogle Scholar3. MachFabreDuckertBorthDucommun RSJARP: Action clinique et metabolique de l'aldosterone (electrocortine), Schweiz. med. Wchnschr. 84: 407, 1954. MedlineGoogle Scholar4. GauntRenziChart RAAJJ: Aldosterone—a review, J. Clin. Endocrinol. and Metabolism 15: 621, 1955. CrossrefGoogle Scholar5. FriedSabo JEF: 9 Alpha-fluoro derivatives of cortisone and hydrocortisone, J. Am. Chem. Soc. 76: 1455, 1954. CrossrefGoogle Scholar6. 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Author, Article, and Disclosure InformationAffiliations: Boston, Massachusetts*Presented as the John Phillips Memorial Lecture at the Thirty-sixth Annual Session of The American College of Physicians, Philadelphia, Pennsylvania, April 27, 1955.From the Departments of Medicine, Harvard Medical School and Peter Bent Brigham Hospital, Boston, Massachusetts.These studies were supported by funds from the National Institutes of Health of the United States Public Health Service; the John A. Hartford Foundation, Incorporated, New York; and the Eugene Higgins Trust of the Harvard Medical School.†Also designated as prednisolone (Δ1-hydrocortisone) and prednisone (Δ1-cortisone). 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ROSENBERG, M.D., F.A.C.P.Triamcinolone in the treatment of allergic conditionsAddison's disease in childrenSynthetic Derivatives of Cortical HormonesObservations on new synthetic antirheumatic steroids and critical evaluation of prednisone therapy in rheumatoid arthritisDie NebennierenrindeThe Treatment of Adrenal DysfunctionClinical and Metabolic Effects of 1-Dehydro-9-Alpha-Fluoro Hydrocortisone AcetateChemie und Biologie neuer CorticoideChemie und Biologie neuer Corticoide 1 November 1955Volume 43, Issue 5Page: 979-1000KeywordsAldosteroneBiologicsExcretionHormonal therapyHormonesHospital medicineMedical servicesOral administrationSteroidsUric acid ePublished: 1 December 2008 Issue Published: 1 November 1955 PDF downloadLoading ...