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In a retrospective analysis of data which evaluates the influence of various factors on the outcome of a clinical assessment of potent analgesie drugs, (1) the method of assaying success of treatment, (2) the influence of different observers in the results obtained, (3) the influence of other factors, viz., age, sex, and weight of the patient, site and duration of operation, and initial severity of pain, were considered. It was concluded that methods based on the subjective assessments of either the patient or observer were valid and sensitive. Changes in spirometrie measurements following treatment were not in themselves valid indices of pain relief, but may be of value in certain circumstances. There was good correlation between the different observers' estimates of pain relief. Low pain severity before treatment was associated with a high er rate of placebo response than was severe pain. Age, sex, body weight, and duration of operation were without significant effect.
LOAN et al. (Fri,) studied this question.