Arterial stiffness serves as a key mechanism linking hypertension to brain structural abnormalities, β-amyloid deposition, and dementia in older adults.
Arterial stiffness is emerging as an important risk marker for poor brain aging and dementia through its associations with cerebral small vessel disease, stroke, β-amyloid deposition, brain atrophy and cognitive impairment. Arterial stiffness directly relates the detrimental effects of hypertension on peripheral organs with dire consequences for the extensive microvasculature structure of the kidneys and brain. In this review, we discuss the evidence linking arterial stiffness, hypertension and brain structural abnormalities in older adults. In particular, we discuss the potential mechanisms linking arterial stiffness to brain β-amyloid deposition and dementia and potential therapeutic strategies to prevent hypertension's adverse effects on the brain.
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Hughes et al. (Wed,) conducted a review in Alzheimer's Disease and Dementia. Arterial stiffness was evaluated. Arterial stiffness serves as a key mechanism linking hypertension to brain structural abnormalities, β-amyloid deposition, and dementia in older adults.
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Neurodegenerative Disease Management
University of Pittsburgh
Wake Forest University
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