Kidney ischemia is proposed as a central mechanism for the parallel activation of the renin-angiotensin and sympathetic nervous systems in chronic kidney disease.
In chronic kidney disease simultaneous activation of the renin-angiotensin and sympathetic systems occurs. Kidney ischemia seems to play a key role in the pathogenesis. This review firstly summarizes experimental and clinical evidence in chronic kidney disease supporting this idea and addresses the possibility that this mechanism is also relevant in some other disease conditions.
Siddiqi et al. (Thu,) studied this question.