Spatially localized 31P magnetic resonance spectroscopy successfully detected regional changes in myocardial high energy phosphates across the myocardial wall in a porcine model of graded ischemia.
Spatially localized 31P magnetic resonance spectroscopy using the Fourier series window technique can successfully detect regional metabolic heterogeneity across the myocardial wall during ischemia.
Previous studies have noted that myocardial blood flow and high energy phosphates are heterogeneous across the myocardial wall during ischemia. In order to determine whether differences in metabolites between the subendocardium and subepicardium could be detected using 31P magnetic resonance spectroscopy, the Fourier series window (FSW) experiment was implemented on a porcine model of graded regional ischemia. FSW experiments using a planar phantom showed a 46% improvement in localization to the subendocardium compared to a one-pulse experiment. Animal studies of graded ischemia demonstrated a gradient in the phosphocreatine to inorganic phosphate ratio in the myocardium that paralleled the gradient in blood flow. These studies demonstrate the ability of spatially localized 31P magnetic resonance spectroscopy to detect regional changes in myocardial high energy phosphates localized to the subepicardium and subendocardium.
Gober et al. (Thu,) conducted a other in Graded regional ischemia. Spatially localized 31P magnetic resonance spectroscopy (Fourier series window experiment) vs. One-pulse experiment was evaluated on Detection of regional changes in myocardial high energy phosphates (phosphocreatine to inorganic phosphate ratio). Spatially localized 31P magnetic resonance spectroscopy successfully detected regional changes in myocardial high energy phosphates across the myocardial wall in a porcine model of graded ischemia.
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