Maximal O2 pulse <12 ml/beat combined with peak VO2 <16 ml/kg.min was associated with a higher risk of all-cause mortality in male veterans with (RR 3.4) and without (RR 2.2) cardiopulmonary disease.
Cohort (n=948)
Does maximal exercise oxygen pulse predict all-cause mortality among male veterans referred for exercise testing?
Maximal O2 pulse provides complementary prognostic information to peak VO2 for predicting mortality in patients undergoing cardiopulmonary exercise testing.
Relative Risk: 3.4
p-value: p=<0.04
BACKGROUND: Maximal oxygen pulse (O(2) pulse) mirrors the stroke volume response to exercise, and should therefore be a strong predictor of mortality. Limited and conflicting data are, however, available on this issue. METHODS: Nine hundred forty-eight participants, classified as those with cardiopulmonary disease (CPD) and those without (non-CPD), underwent cardiopulmonary exercise testing (CPX) for clinical reasons between 1993 and 2003. The ability of maximal O(2) pulse and maximal oxygen uptake (peak VO(2)) to predict mortality was investigated using proportional hazards and Akaike information criterion analyses. All-cause mortality was the endpoint. RESULTS: Over a mean follow-up of 6.3+/-3.2 years, there were 126 deaths. Maximal O(2) pulse, expressed in either absolute or relative to age-predicted terms, and peak VO(2) were significant and independent predictors of mortality in those with and without CPD (P or =12 ml/beat and or =16 ml/(kg.min) respectively) were established by the area under the receiver-operating-characteristic curve. The relative risks of mortality were 3.4 and 2.2 (CPD and non-CPD, respectively) among participants with both maximal O(2) pulse and peak VO(2) responses below these cut-points compared with participants with both responses above these cut-points. CONCLUSION: These results indicate that maximal O(2) pulse is a significant predictor of mortality in patients with and without CPD. The addition of absolute and relative O(2) pulse data provides complementary information for risk-stratifying heterogeneous participants referred for CPX and should be routinely included in the CPX report.
Oliveira et al. (Mon,) conducted a cohort in Cardiopulmonary disease (CPD) and non-CPD (n=948). Maximal exercise oxygen pulse <12 ml/beat and peak VO2 <16 ml/(kg.min) vs. Maximal O2 pulse ≥12 ml/beat and peak VO2 ≥16 ml/(kg.min) was evaluated on All-cause mortality (RR 3.4 (CPD) and 2.2 (non-CPD), p=<0.04). Maximal O2 pulse <12 ml/beat combined with peak VO2 <16 ml/kg.min was associated with a higher risk of all-cause mortality in male veterans with (RR 3.4) and without (RR 2.2) cardiopulmonary disease.