The lowest Life's Essential 8 scores (<50 points) were strongly associated with higher odds of CCTA-stenosis (OR 4.18; 95% CI 3.56-4.91) compared to the highest scores (≥80 points).
Cross-Sectional (n=24,819)
Do Life's Essential 8 and Life's Simple 7 scores predict subclinical coronary atherosclerosis in a middle-aged population?
The Life's Essential 8 score shows a strong, graded, inverse association with subclinical coronary atherosclerosis and may be a useful tool for monitoring cardiovascular health.
Odds Ratio: 4.18 (95% CI 3.56–4.91)
OBJECTIVE: To examine the associations between the American Heart Association scores ("Life's Essential 8" LE8 and "Life's Simple 7" LS7) and 2 subclinical coronary atherosclerosis indicators: coronary computed tomographic angiography (CCTA)-stenosis and coronary artery calcium (CAC). PATIENTS AND METHODS: We included a population-based sample, aged 50 to 64 years, recruited between 2013 and 2018 from the Swedish Cardiopulmonary Bioimage Study (n=24,819, 50.3% women). CCTA-stenosis was graded as no stenosis, stenosis (1%-49%) or severe stenosis (≥50%), whereas CAC was graded as 0, 1 to 99, 100 to 399, or ≥400 Agatston units. Multinomial logistic regression and receiver operating characteristic (ROC) curves were used to study the associations between cardiovascular health scores and subclinical coronary atherosclerosis. RESULTS: Odds ratios (ORs) for CCTA-stenosis and severe CCTA-stenosis between the lowest (<50 points) vs the highest (≥80 points) LE8 group were 4.18 (95% CI, 3.56 to 4.91) and 11.17 (95% CI, 8.36 to 14.93), respectively. For corresponding CAC results, ORs were 3.36 (95% CI, 2.84 to 3.98), 7.72 (95% CI, 6.03 to 9.89), and 14.94 (95% CI, 10.47 to 21.31) for CAC scores of 1 to 99, 100 to 399, and ≥400, respectively. Area under ROC curves for predicting any stenosis were 0.642 (95% CI, 0.635 to 0.649) and 0.631 (95% CI, 0.624 to 0.638, P<.001) for LE8 and LS7, respectively. CONCLUSION: Our data indicate that LE8 showed a strong, graded, and inverse association with CCTA-stenosis and CAC score. The capacity to predict CCTA-stenosis was comparable between LE8 and LS7, although LE8 had slightly higher prediction capacity of any stenosis. This study provides novel evidence that the LE8 score may be a useful tool for monitoring cardiovascular health.
Herráiz-Adillo et al. (Sat,) conducted a cross-sectional in Subclinical coronary atherosclerosis (n=24,819). Lowest Life's Essential 8 score (<50 points) vs. Highest Life's Essential 8 score (≥80 points) was evaluated on CCTA-stenosis (OR 4.18, 95% CI 3.56-4.91). The lowest Life's Essential 8 scores (<50 points) were strongly associated with higher odds of CCTA-stenosis (OR 4.18; 95% CI 3.56-4.91) compared to the highest scores (≥80 points).