What is the clinical evidence from this study?

Study design: Other. Population: Acute ischemia. Intervention: Acute ischemia induced by coronary ligation vs. Baseline. Primary outcome: Angle of cardiac rotation and maximum Angular Velocity.

September 1, 2008

Assessment of cardiac rotation by means of gyroscopic sensors

Key Result

Acute ischemia induced by coronary ligation caused a significant decrease in the angle of cardiac rotation (-37±6%) and maximum angular velocity (-21±4%) measured by epicardial gyroscopic sensors.

Structured PICO

Can gyroscopic sensors accurately quantify cardiac rotation and detect LV twist alterations during acute ischemia in an animal model?

Population

Animal study evaluating the use of epicardial gyroscopic sensors to quantify left ventricular twist dynamics at baseline and after acute ischemia induced by coronary ligation.

Exposure

Three gyroscopes epicardially glued at different levels along the LV long axis (apex, middle, base)

Comparator

Baseline measurements before acute ischemia induced by coronary ligation

Outcome

Angular Velocity (Ang V) and Angle of cardiac rotation (Angle) evaluated against hemodynamic measurements of LV pressure (LVP, LVdP/dt)surrogate

Gyroscopic sensors can feasibly assess cardiac rotation and detect LV twist alterations during acute ischemia in an animal model.

Abstract

During the cardiac cycle, contraction of the helically oriented myocardial fibers results in torsion, a wringing motion as the cardiac apex rotates with respect to the base about the Left Ventricle (LV) long axis. We evaluated in animals the use of gyroscopic sensors to quantify cardiac rotation, which was demonstrated to be a sensitive index of cardiac function. Three gyroscopes were epicardially glued at different levels along the LV long axis (apex, middle, base) to assess LV twist dynamics: Angular Velocity (Ang V) and Angle of cardiac rotation (Angle) were measured and evaluated against hemodynamic measurements of LV pressure (LVP, LVdP/dt), at baseline and after acute ischemia induced by coronary ligation. Results demonstrated the feasibility of assessing cardiac rotation and LV twist alterations by means of gyroscopic sensors, especially at apical level: compared with baseline, acute ischemia caused a significant decrease of both Angle and the maximum value of Ang V (mean variation of −37±6% and −21±4%, respectively); a concomitant reduction of LVdP/dt MAX (−43±4%) was observed.

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