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Mild cognitive impairment (MCI) is a transitional stage between healthy aging and dementia, underscoring the urgent need for accessible, low-cost, and scalable preventive strategies beyond pharmacological approaches. In this single-blind randomized feasibility trial (NCT06814483), 32 older adults with MCI were assigned to a 12-week, telehealth-delivered, computer-based multimodal mind–body approach (cbMMBA) or an active computer-based cognitive fitness program (cbCFP) used as control condition. Recruitment rate was 66.7%; retention rate was 78.6% vs. 100.0% (cbMMBA vs. cbCFP); intervention fidelity was 85.3% vs. 98.2%; satisfaction score was 4.80 vs. 4.47; and there were no serious intervention-related adverse events. Exploratory analyses indicated domain-specific cognitive improvements in both cbMMBA and cbCFP, favoring cbMMBA in memory, language, and visuospatial abilities, with within-group gains in global cognition. These findings support the feasibility, safety, and acceptability of a fully remote mind–body program for older adults with MCI; however, as a feasibility study, it was not powered to establish efficacy, and larger, longer trials are needed to confirm benefits and scalability for equitable dementia prevention.
Liu et al. (Mon,) studied this question.