Fluoroacyclic Nucleoside Phosphates and Phosphonates as Potential Class of Antiviral Agents

Key Points

• The study aims to synthesize fluorinated acyclonucleos(t)ides and their prodrugs as potential antiviral agents.
• Developed two synthesis methods involving early- or late-stage nucleic base introduction.
• Focused on the preparation of tetrasubstituted fluoroalkenes as key intermediates.
• Produced known drugs and their analogues during the synthesis process.
• Successfully synthesized various fluorinated acyclonucleos(t)ides.
• Demonstrated the versatility of tetrasubstituted fluoroalkenes in creating target compounds.