AVITHRAPID - Standard Operating Procedure - PLC3 cells differentiation before HEV infection

Key Result

PLC3 cell differentiation is required prior to HEV infection when evaluating the antiviral effects of compounds.

Key Points

• The aim is to evaluate the antiviral effect of a compound on differentiated PLC3 cells infected with HEV.
• PLC3 cell line was differentiated before infection with HEV.
• Compounds were applied to evaluate their antiviral effects post differentiation.
• Differentiated PLC3 cells show improved antiviral responses to the compound against HEV.
• Infection rates in differentiated cells were significantly reduced compared to non-differentiated cells.