Acute leukemias with FUS gene rearrangements predominantly present as acute myeloid leukemia, whereas those with EWSR1 rearrangements more commonly present as B-cell acute lymphoblastic leukemia and mixed phenotypic acute leukemia.
This mini-review summarizes the unique clinical and pathological features of acute leukemias with EWSR1 or FUS gene rearrangements.
Acute leukemias with chimeric fusion genes involving FET (FUS, EWSR1, and TAF15) family proteins and ETS (E26 transformation-specific)-like transcription factors often present with unique clinical and pathological characteristics. This mini-review aims to summarize the clinical and pathological features of acute leukemia cases harboring rearrangements involving the fused in sarcoma (FUS) or Ewing sarcoma breakpoint region 1 (EWSR1) genes.
Ding et al. (Mon,) conducted a review in Acute leukemia with EWSR1 or FUS gene rearrangements. FUS or EWSR1 gene rearrangements was evaluated. Acute leukemias with FUS gene rearrangements predominantly present as acute myeloid leukemia, whereas those with EWSR1 rearrangements more commonly present as B-cell acute lymphoblastic leukemia and mixed phenotypic acute leukemia.