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A CrystallographicInvestigation of a Human IgG Immunoglobulin"antigenic type ( = y1 chains).With solutions containing either 0.2 or 10 mg of Meg protein per ml, a molecular weight of 145,000 was obtained by the sedimentation equilibrium method of Yphantis (9).At the same protein concentrations the sedimentation coefficients were 6.53 S and 6.68 S, respectively.These values are low in comparison to the usual range (6.6 to 7.2 S, mol wt 150,000 to 160,000) reported for human IgG proteins (10).
Edmundson et al. (Fri,) studied this question.
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