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Ninety-four patients with inflammatory acne were treated with demethylchlortetracycline hydrochloride in a doubleblind, modified, crossover study. Good to excellent responses were obtained in 58% of the patients receiving demethylchlortetracycline, and in 24% of those receiving placebo. The drug, when used in a dosage of 150 mg three times daily without concomitant therapy, primarily affected inflammatory papules and pustules. Response to treatment was determined by counting lesions on the involved sites.
Joseph A. Witkowski (Mon,) studied this question.