Key points are not available for this paper at this time.
Investigators have long recognized the potential importance of protein degradation as a mechanism for regulating levels of cellular proteins (1-3). Nevertheless, only recent studies of the ubiquitin-proteasome pathway have shown how extensively proteolysis is involved in the regulation of crucial cellular processes such as: progression of the cell cycle, oncogenesis, transcription, development, growth and atrophy of developed tissues, flux of substrates through metabolic pathways, selective elimination of abnormal proteins, and antigen processing.
Demartino et al. (Sun,) studied this question.