Functional abnormalities of actin-binding proteins contribute to the development of cardiac hypertrophy by affecting the structural basis for contractile function in cardiomyocytes.
The heart reacts to a large number of pathological stimuli through cardiac hypertrophy, which finally can lead to heart failure. However, the molecular mechanisms of cardiac hypertrophy remain elusive. Actin participates in the formation of highly differentiated myofibrils under the regulation of actin-binding proteins (ABPs), which provides a structural basis for the contractile function and morphological change in cardiomyocytes. Previous studies have shown that the functional abnormality of ABPs can contribute to cardiac hypertrophy. Here, we review the function of various actin-binding proteins associated with the development of cardiac hypertrophy, which provides more references for the prevention and treatment of cardiomyopathy.
Pan et al. (Fri,) conducted a review in Cardiac hypertrophy. Actin-binding proteins (ABPs) was evaluated. Functional abnormalities of actin-binding proteins contribute to the development of cardiac hypertrophy by affecting the structural basis for contractile function in cardiomyocytes.