Patients with coronary artery disease had significantly higher serum endothelin-1 levels than healthy controls (2.44 vs 1.76 pg/mL, p<0.001), with the highest levels in those with concurrent diabetes.
Cross-Sectional (n=305)
No
Are serum endothelin-1 levels elevated in patients with coronary artery disease and diabetes mellitus compared to healthy controls?
Serum endothelin-1 levels are significantly elevated in patients with stable coronary artery disease, particularly those with concomitant diabetes mellitus, suggesting a potential role for ET-1 in the pathophysiology of CAD in diabetics.
Absolute Event Rate: 2.44% vs 1.76%
p-value: p=<0.001
Diabetes mellitus (DM) increases risk of coronary artery disease (CAD). Endothelin-1 (ET-1) is a potential biomarker of endothelial dysfunction. This study aimed to evaluate ET-1 level in CAD patients and its relationship with DM. The cross-sectional design included subjects with angiographically proven CAD and controls among Indonesian. DM was defined by medical history and anti-diabetics use. Serum ET-1 level was measured in both subject groups. We recruited 305 subjects, 183 CAD patients and 122 controls. CAD subjects had higher percentage of males, DM, hypertension, dyslipidemia, smoking, family history of cardiovascular disease, and obesity. ET-1 level was significantly higher in CAD than in controls (2.44 ± 1.49 pg/mL vs. 1.76 ± 0.83 pg/mL; p < 0.001). Increased ET-1 level was significantly associated with DM and dyslipidemia. The highest ET-1 level was observed in CAD with DM, followed by CAD non-DM (2.79 ± 1.63 pg/mL vs. 2.29 ± 1.40 pg/mL; p = 0.023). Among controls, ET-1 level was the lowest in non-DM subjects. Female CAD had higher proportion of DM; however, ET-1 level was similar to male CAD with DM. In conclusion, an increased ET-1 level was significantly associated with DM in patients with CAD. Further research should investigate the potential role of ET-1 receptor antagonists in the secondary prevention of CAD with DM.
Inggriani et al. (Fri,) conducted a cross-sectional in Coronary artery disease and diabetes mellitus (n=305). Coronary artery disease vs. Healthy controls was evaluated on Serum endothelin-1 (ET-1) level (p=<0.001). Patients with coronary artery disease had significantly higher serum endothelin-1 levels than healthy controls (2.44 vs 1.76 pg/mL, p<0.001), with the highest levels in those with concurrent diabetes.