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Feeding of bile acid binding polymeric organic bases inhibited cholesterol rise and aortic. plaque formation in cholesterol-fed cockerels, lowered plasma cholesterol concentrations in normocholesterolemic cockerels and dogs, and increased fecal bile acid and sterol output in a dog. In experiments lasting as long as one year these substances have not produced visible toxic effects. They are thought to act by binding the bile acids in the intestinal tract.
Tennent et al. (Sat,) studied this question.
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