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Journal Article Statistical and Ethical Issues in the Design and Conduct of Phase I and II Clinical Trials of New Anticancer Agents Get access Mark J. Ratain, Mark J. Ratain Search for other works by this author on: Oxford Academic PubMed Google Scholar Rosemarie Mick, Rosemarie Mick Search for other works by this author on: Oxford Academic PubMed Google Scholar Richard L. Schilsky, Richard L. Schilsky Search for other works by this author on: Oxford Academic PubMed Google Scholar Mark Siegler Mark Siegler Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 85, Issue 20, 20 October 1993, Pages 1637–1643, https://doi.org/10.1093/jnci/85.20.1637 Published: 20 October 1993 Article history Received: 04 March 1993 Revision received: 26 June 1993 Accepted: 02 August 1993 Published: 20 October 1993
Ratain et al. (Wed,) studied this question.