Addition of perioperative β-blockade was associated with reduced 30-day mortality (OR 0.52; 95% CI 0.33-0.83; P=0.006), whereas withdrawal was associated with increased mortality (OR 3.93).
Cohort (n=38,779)
No
Does the pattern of perioperative β-blockade use affect 30-day and 1-year mortality in surgical patients?
Perioperative β-blockade addition or continuation reduces 30-day and 1-year mortality, while withdrawal significantly increases mortality risk.
Odds Ratio: 0.52 (95% CI 0.33–0.83)
p-value: p=0.006
BACKGROUND: The 1996 atenolol study provided evidence that perioperative β-adrenergic receptor blockade (β-blockade) reduced postsurgical mortality. In 1998, the indications for perioperative β-blockade were codified as the Perioperative Cardiac Risk Reduction protocol and implemented at the San Francisco Veterans Administration Medical Center, San Francisco, California. The present study analyzed the association of the pattern of use of perioperative β-blockade with perioperative mortality since introduction of the Perioperative Cardiac Risk Reduction protocol. METHODS: Epidemiologic analysis of the operations undertaken since 1996 at the San Francisco Veterans Administration Medical Center was performed. The pattern of use of perioperative β-blockade was divided into four groups: None, Addition, Withdrawal, and Continuous. Logistic regression, survival analysis, and propensity analysis were performed. RESULTS: A total of 38,779 operations were performed between 1996 and 2008. In patients meeting Perioperative Cardiac Risk Reduction indications for perioperative β-blockade, Addition is associated with a reduction in 30-day (odds ratio OR, 0.52; 95% confidence interval CI, 0.33 to 0.83; P = 0.006) and 1-yr mortality (OR, 0.64; 95%, CI 0.51 to 0.79; P < 0.0001). Continuous is associated with a reduction in 30-day (OR, 0.68; 95% CI, 0.47 to 0.98; P = 0.04) and 1-yr mortality (OR, 0.82; 95% CI, 0.67 to 1.0; P = 0.05). Withdrawal is associated with an increase in 30-day (OR 3.93, 95% CI, 2.57 to 6.01; P less than 0.0001) and 1-yr mortality (OR, 1.96; 95% CI, 1.49 to 2.58; P < 0.0001). CONCLUSION: Perioperative β-blockade administered according to the Perioperative Cardiac Risk Reduction protocol is associated with a reduction in 30-day and 1-yr mortality. Perioperative withdrawal of β-blockers is associated with increased mortality.
Wallace et al. (Fri,) conducted a cohort in Patients undergoing surgery meeting indications for perioperative β-blockade (n=38,779). Perioperative β-blockade (Addition, Continuous, or Withdrawal) vs. None (no perioperative β-blockade) was evaluated on 30-day mortality (Addition vs None) (OR 0.52, 95% CI 0.33 to 0.83, p=0.006). Addition of perioperative β-blockade was associated with reduced 30-day mortality (OR 0.52; 95% CI 0.33-0.83; P=0.006), whereas withdrawal was associated with increased mortality (OR 3.93).