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Deficiency in PDIM/PGL virulence lipids in Mycobacterium marinum causes significant protein dysregulation, alters ESAT-6 System-1 export, and specifically decreases the export of proteins with low isoelectric points. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

December 29, 2025Microbiology Resource Announcements3 citationsOpen Access

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PDIM/PGL-deficient Mycobacterium marinum shows disrupted protein secretion measured with bottom-up label-free quantitative analysis in data-dependent acquisition mode on a timsTOF Pro 2 mass spectrometer

SWSimon D. WeaverUniversity of Notre Dame DHDaniel D. HuUniversity of Notre Dame BJBradley S. JonesUniversity of Notre Dame

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Abstract

ABSTRACT We investigated the chemical and functional consequences of a Mycobacterium marinum strain deficient in phthiocerol dimycocerosate and phenolic glycolipid (PDIM/PGL) virulence lipids using quantitative proteomics. The significant dysregulation of 1,006 proteins and altered ESAT-6 System-1 export and virulence were measured. PDIM/PGL deficiency specifically decreased the export of proteins with low isoelectric points.

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Weaver et al. (Mon,) studied this question.

synapsesocial.com/papers/6a209cf301bc09701ff36900 https://doi.org/https://doi.org/10.1128/mra.01161-25

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