Design
Review
Key result
Metabolic remodeling and loss of metabolic flexibility precede and sustain functional and structural remodeling in the stressed and failing heart.
Authors
Loading...
Metabolic targets merit prospective HF trials; review-level data leaves open whether modulating flexibility improves outcomes.
This review highlights the critical role of metabolic flexibility and remodeling in cardiac function and heart failure, suggesting metabolic modulation as a potential therapeutic target.
Taegtmeyer et al. (2005) conducted a review in Heart failure. Metabolic remodeling and loss of metabolic flexibility precede and sustain functional and structural remodeling in the stressed and failing heart.