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A female patient with chronic myelogenous leukemia was found to have 47, XX, + D in 100% of her bone marrow cells. There was no Ph1 chromosome. Fluorescent staining showed that the extra D group chromosome was most likely a No. 13 chromosome. Both lymphocyte and skin fibroblast cultures revealed a normal female karyotype, which indicated that the abnormal karyotype was not constitutional but an aberration occurring only in the leukemic bone marrow cells. To our knowledge, such an aberration has not been reported previously as an isolated abnormality present in leukemic marrow cells.
Hsu et al. (Wed,) studied this question.