Serum 4-HNE decreased less over 6 months in CAD patients with depression compared to those without, and its reduction was significantly associated with decreased depressive symptom severity.
Cohort (n=120)
Are longitudinal changes in lipid peroxidation markers associated with depressive symptoms in CAD patients undergoing cardiac rehabilitation?
The lipid peroxidation marker 4-HNE is associated with the trajectory of depressive symptoms in CAD patients during cardiac rehabilitation.
Depressive symptoms in patients with coronary artery disease (CAD) attenuate the cardiovascular benefits of cardiac rehabilitation (CR). Given that oxidative stress may be an important mechanism underlying depression, this study aimed to understand the longitudinal relationship between lipid peroxidation markers and depression in CAD. Serum levels of early (lipid hydroperoxides, LPH) and late (4‑hydroxy‑2-nonenal, 4-HNE; 8-isoprotane, 8-ISO) lipid peroxidation markers were measured in 120 CAD patients undergoing CR. The Structured Clinical Interview for DSM Axis I Disorders - Depression Module (SCID) was used to diagnose depression at baseline and the Center for Epidemiological Studies Depression Scale (CES-D) was used to measure depressive symptom severity. Multivariate mixed models compared the trajectories of serum LPH, 4-HNE, and 8-ISO between depressed and non-depressed CAD patients undergoing 6 months of CR. Similar models evaluated the associations between serum LPH, 4-HNE, and 8-ISO and CES-D score over the course of CR. Serum 4-HNE decreased less in CAD patients with depression compared to those without. In addition, a decrease in 4-HNE concentrations was significantly associated with a decrease in CES-D scores over 6 months. These findings suggest that 4-HNE may be an important marker of depressive symptoms in CAD and may be involved in its progression.
Rosen et al. (Fri,) conducted a cohort in Coronary artery disease (n=120). Depression vs. No depression was evaluated on Trajectories of serum LPH, 4-HNE, and 8-ISO and CES-D score. Serum 4-HNE decreased less over 6 months in CAD patients with depression compared to those without, and its reduction was significantly associated with decreased depressive symptom severity.