Photocontrolled immunotherapy: a BODIPY-caged MSA-2 for spatiotemporal activation of STING with visible light

Key Points

• This research aims to investigate the use of a BODIPY-caged MSA-2 for controlled activation of STING using visible light in immunotherapy.
• Developed a BODIPY-caged MSA-2 compound
• Assessed its capacity for visible light-controlled STING activation
• Evaluated spatiotemporal regulation of immunotherapy effects
• Enabled targeted activation of STING using visible light
• Demonstrated precise spatial regulation of immune response
• Showed potential for improved immunotherapy activation timing