OBJECTIVES: To explore the links between SES mobility and dementia incidence, cognitive function, and neuroimaging markers, and to assess whether cardiovascular health mediates these associations. METHODS: childhood and adulthood SES, and categorized into stable low, upward mobility, downward mobility, stable medium and stable high. Cox and linear regression models were conducted to examine associations of SES mobility with dementia risk, cognitive function, and neuroimaging markers. RESULTS: = -163.97, 95% CI: -221.36, -106.57) compared to stable high SES. The above associations were mediated by Life's Essential 8 score, which was measured simultaneously with SES mobility. CONCLUSION: Disadvantaged SES mobility in transition between childhood and adulthood SES was related to adverse brain health and cardiovascular health mediated these relationships.
Liu et al. (Tue,) studied this question.