What question did this study set out to answer?

The aim is to evaluate the therapeutic potential of fisetin in neurodegenerative diseases and the associated molecular mechanisms.

June 4, 2026

Fisetin and Neurodegeneration: From Preclinical Studies to PotentialClinical Applications

Key Points

The aim is to evaluate the therapeutic potential of fisetin in neurodegenerative diseases and the associated molecular mechanisms.
Review of preclinical studies and in vitro research on fisetin's effects in neurodegenerative diseases.
Analysis of key molecular pathways influenced by fisetin, including Nrf2/ARE, PI3K/Akt, and NF-κB.
Discussion on the challenges of fisetin's pharmacokinetics and bioavailability in clinical application.
Fisetin reduces oxidative stress, inflammation, and apoptosis, enhancing neuronal survival.
Behavioral evaluations show improved motor coordination, synaptic plasticity, and cognitive function in animal models.
Clinical translation is limited due to bioavailability issues, necessitating further research and improved delivery methods.

Abstract

Neurodegenerative diseases (NDs), like Alzheimer's disease, Parkinson's disease, Huntington's disease, amyotrophic lateral sclerosis, and multiple sclerosis, pose significant challenges due to their gradual deterioration and limited available treatments. Fisetin, a naturally occurring flavonoid, has gained attention for its neuroprotective properties. This review explores the therapeutic potential of fisetin in NDs, focusing on its molecular processes and signaling pathways. Additionally, fisetin exhibits significant protective properties, particularly in reducing oxidative stress, neuroinflammation, and apoptosis. It enhances neuronal survival and reduces neuroinflammation by regulating key pathways, such as Nrf2/ARE, PI3K/Akt, and NF-κB. It also has anti-inflammatory, anti-apoptotic, and antioxidant actions. It stimulates autophagic processes, aiding in the removal of harmful protein aggregates, like tau tangles and amyloid plaques, which are hallmarks of NDs. Fisetin, as demonstrated through behavioral evaluations in animal models, has been found to improve motor coordination, synaptic plasticity, and cognitive function. Furthermore, fisetin's potential as a neuroprotective drug is emphasized by its role in enhancing autophagy and reducing tau and amyloid pathology. Research has shown its efficacy in enhancing neural resilience, synaptic plasticity, and cognitive function in both preclinical and in vitro settings. However, clinical translation remains limited due to challenges in pharmacokinetics and bioavailability, despite robust experimental evidence. Further clinical trials are needed to evaluate the safety and efficacy of fisetin, especially in early-stage NDs, explore potential synergistic effects, and understand the molecular interactions. The review demonstrates fisetin's therapeutic potential, recent research, and future strategies for NDs, highlighting bioavailability limitations and the need for new formulations or delivery systems.

AI에게 질문

Bookmark