Distinct Adsorption Behavior and Structures of Cell-Penetrating Peptides at a Model Lipid Membrane Interface: A Heterodyne-Detected Vibrational Sum Frequency Generation Spectroscopy Study

Key Points

• This research aims to uncover the adsorption behavior and structural interactions of cell-penetrating peptides at lipid membrane interfaces.
• Utilized heterodyne-detected vibrational sum frequency generation spectroscopy to analyze peptide interaction.
• Examined distinct structures of arginine-rich cell-penetrating peptides at model lipid membranes.
• Identified unique adsorption behaviors of cell-penetrating peptides at the lipid membrane interface.
• Revealed specific structural changes in peptides upon interaction with the lipid environment.