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Awareness of the neurologic complications of Mycoplasma pneumoniae is increasing as is indicated by two recent review articles on this subject1,2 and by the appearance of more frequent isolated case reports on the same subject.3-6 The association of M. pneumoniae with central nervous system dysfunction has been based mainly on clinical observations and serological data from serial serum samples. Direct evidence of an etiologic relationship is still lacking, for attempts at isolation of this organism from the cerebrospinal fluid (CSF) of brain tissue have been uniformly unsuccessful. In fact, most of the serological support for this association has been established from serum samples rather than from studies of the CSF.
Klimek et al. (Thu,) studied this question.