Larger artery surface of TAWSS below critical value generally goes with smaller pulse rate, larger stenosis severity, and distance between stenosis and tortuosity, though spiral tortuosity suppresses atherosclerosis risks compared to curved.
Computational fluid dynamics modeling demonstrates that spiral tortuosity in coronary arteries may suppress atherosclerosis risk compared to curved tortuosity.
Tortuosity in coronary artery has been found to be greatly related to the potential sites of stenosis in these last years. Many investigations have been carried out based on the tool of Computational Fluid Dynamics (CFD) mainly focusing on the influences of curved artery in blood flow. Within the limited investigations of coupling between stenosis and tortuosity, the stenosis has been considered to be located at the tortuous segment. However, with recent clinical studies, the case of stenosis occurred at non-tortuous segment before tortuosities has been confirmed which has not been paid enough attention yet. Therefore, the present study aims to investigate the disturbed streamlines and hemodynamics in curved and spiral artery considering symmetrical and asymmetrical stenosis upstream these tortuosities. Different stenosis severities, pulse rates and distances between stenosis and tortuosity as controlling parameters have been studied. The distribution of time averaged wall shear stress (TAWSS) and streamlines through tortuous segment have been displayed in order to determine the potential disease sites. Artery surface of TAWSS below critical value has been quantified as well to evaluate the risks of atherosclerosis. The results reveal that larger artery surface of TAWSS below critical value generally goes with smaller pulse rate, larger stenosis severity and distance between stenosis and tortuosity both for curved and spiral artery. However, exceptions were found in the cases of distance of 6 mm in curved artery with symmetrical stenosis and stenosis severity of 50% in spiral artery. Moreover, the spiral tortuosity tends to suppress the potential risks of atherosclerosis compared to curved tortuosity.
Song et al. (Fri,) conducted a other in Coronary artery stenosis and tortuosity. Curved and spiral artery models with symmetrical and asymmetrical stenosis was evaluated on Time averaged wall shear stress (TAWSS) and streamlines. Larger artery surface of TAWSS below critical value generally goes with smaller pulse rate, larger stenosis severity, and distance between stenosis and tortuosity, though spiral tortuosity suppresses atherosclerosis risks compared to curved.
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