Neoadjuvant chemotherapy significantly reduced mean anaerobic threshold from 15.3 at baseline to 11.8 ml/kg/min immediately post-treatment, with no recovery by 4 weeks (P<0.010).
Observational (n=31)
Does neoadjuvant chemotherapy reduce cardiorespiratory reserve in patients with oesophagogastric cancer?
Neoadjuvant chemotherapy significantly reduces cardiorespiratory reserve in patients with oesophagogastric cancer, with no recovery observed up to 4 weeks post-treatment prior to surgery.
Absolute Event Rate: 11.8% vs 15.3%
p-value: p=<0.010
Abstract Background Neoadjuvant chemotherapy may have a detrimental impact on cardiorespiratory reserve. Determination of oxygen uptake at the anaerobic threshold by cardiopulmonary exercise testing (CPET) provides an objective measure of cardiorespiratory reserve. Anaerobic threshold can be used to predict perioperative risk. A low anaerobic threshold is associated with increased morbidity after oesophagogastrectomy. The aim of this study was to establish whether neoadjuvant chemotherapy has an adverse effect on fitness, and whether there is recovery of fitness before surgery for oesophageal and gastric adenocarcinoma. Methods CPET was completed before, immediately after (week 0), and at 2 and 4 weeks after neoadjuvant chemotherapy. The ventilatory anaerobic threshold and peak oxygen uptake (Vo2 peak) were used as objective, reproducible measures of cardiorespiratory reserve. Anaerobic threshold and Vo2 peak were compared before and after neoadjuvant chemotherapy, and at the three time intervals. Results Some 31 patients were recruited. The mean anaerobic threshold was lower following neoadjuvant treatment: 15·3 ml per kg per min before chemotherapy versus 11·8, 12·1 and 12·6 ml per kg per min at week 0, 2 and 4 respectively (P 0·010). Measurements were also significantly different at each time point (P 0·010). The same pattern was noted for Vo2 peak between values before chemotherapy (21·7 ml per kg per min) and at weeks 0, 2 and 4 (17·5, 18·6 and 19·3 ml per kg per min respectively) (P 0·010). The reduction in anaerobic threshold and Vo2 peak did not improve during the time between completion of neoadjuvant chemotherapy and surgery. Conclusion There was a decrease in cardiorespiratory reserve immediately after neoadjuvant chemotherapy that was sustained up to the point of surgery at 4 weeks after chemotherapy.
Navidi et al. (Fri,) conducted a observational in Oesophagogastric cancer (n=31). Neoadjuvant chemotherapy vs. Baseline (before chemotherapy) was evaluated on Mean anaerobic threshold (ml/kg/min) (p=<0.010). Neoadjuvant chemotherapy significantly reduced mean anaerobic threshold from 15.3 at baseline to 11.8 ml/kg/min immediately post-treatment, with no recovery by 4 weeks (P<0.010).
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