Active cancer in chemotherapy-naïve patients was independently associated with smaller cardiac chambers, increased strain amplitude, and elevated native T1 compared with healthy volunteers.
Observational (n=483)
Does active chemotherapy-naïve cancer alter cardiac chamber size, function, and myocardial tissue health compared to healthy volunteers?
Active, chemotherapy-naïve cancer is independently associated with subclinical alterations in cardiac chamber size, mechanics, and tissue health on CMR compared to healthy volunteers.
Background The overlap between cancer and cardiovascular care continues to expand, with intersections emerging before, during, and following cancer therapies. To date, emphasis has been placed on how cancer therapeutics influence downstream cardiac health. However, whether active malignancy itself influences chamber volumes, function, or overall myocardial tissue health remains uncertain. We sought to perform a comprehensive cardiovascular magnetic resonance-based evaluation of cardiac health in patients with chemotherapy-naïve cancer with comparison with a healthy volunteer population. Methods and Results Three-hundred and eighty-one patients with active breast cancer or lymphoma before cardiotoxic chemotherapy exposure were recruited in addition to 102 healthy volunteers. Both cohorts underwent standardized cardiovascular magnetic resonance imaging with quantification of chamber volumes, ejection fraction, and native myocardial T1. Left ventricular mechanics were incrementally assessed using three-dimensional myocardial deformation analysis, providing global longitudinal, circumferential, radial, and principal peak-systolic strain amplitude and systolic strain rate. The mean age of patients with cancer was 53.8±13.4 years; 79% being women. Despite similar left ventricular ejection fraction, patients with cancer showed smaller chambers, increased strain amplitude, and systolic strain rate in both conventional and principal directions, and elevated native T1 versus sex-matched healthy volunteers. Adjusting for age, sex, hypertension, and diabetes mellitus, the presence of cancer remained associated with these cardiovascular magnetic resonance parameters. Conclusions The presence of cancer is independently associated with alterations in cardiac chamber size, function, and objective markers of tissue health. Dedicated research is warranted to elucidate pathophysiologic mechanisms underlying these findings and to explore their relevance to the management of patients with cancer referred for cardiotoxic therapies.
Labib et al. (Wed,) conducted a observational in Chemotherapy-naïve active breast cancer or lymphoma (n=483). Active cancer (chemotherapy-naïve) vs. Healthy volunteers was evaluated on Cardiac chamber volumes, ejection fraction, native myocardial T1, and left ventricular mechanics. Active cancer in chemotherapy-naïve patients was independently associated with smaller cardiac chambers, increased strain amplitude, and elevated native T1 compared with healthy volunteers.
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