An 8-month collaborative care intervention is designed to test whether it can produce an effect size of ≥0.5 improvement in HRQoL at 8 months post-CABG compared to usual care.
RCT (n=450)
Yes
Does an 8-month nurse-delivered telephone-based collaborative care strategy improve health-related quality of life in depressed post-CABG patients?
The Bypassing the Blues study is designed to evaluate whether a nurse-delivered collaborative care intervention improves health-related quality of life in depressed patients following CABG surgery.
OBJECTIVE: To present the design of the Bypassing the Blues (BtB) study to examine the impact of a collaborative care strategy for treating depression among patients with cardiac disease. Coronary artery bypass graft (CABG) surgery is one of the most common and costly medical procedures performed in the US. Up to half of post-CABG patients report depressive symptoms, and they are more likely to experience poorer health-related quality of life (HRQoL), worse functional status, continued chest pains, and higher risk of cardiovascular morbidity independent of cardiac status, medical comorbidity, and the extent of bypass surgery. METHODS: BtB was designed to enroll 450 post-CABG patients from eight Pittsburgh-area hospitals including: (1) 300 patients who expressed mood symptoms preceding discharge and at 2 weeks post hospitalization (Patient Health Questionnaire (PHQ-9) >or=10); and (2) 150 patients who served as nondepressed controls (PHQ-9 or=0.5 improvement in HRQoL at 8 months post CABG, as measured by the SF-36 Mental Component Summary score. Secondary hypotheses will examine the impact of our intervention on mood symptoms, cardiovascular morbidity, employment, health services utilization, and treatment costs. RESULTS: Not applicable. CONCLUSIONS: This effectiveness trial will provide crucial information on the impact of a widely generalizable evidence-based collaborative care strategy for treating depressed patients with cardiac disease.
Rollman et al. (Sun,) conducted a rct in Post-CABG depression (n=450). Nurse-delivered telephone-based collaborative care vs. Usual care was evaluated on Improvement in HRQoL at 8 months post CABG (SF-36 Mental Component Summary score). An 8-month collaborative care intervention is designed to test whether it can produce an effect size of ≥0.5 improvement in HRQoL at 8 months post-CABG compared to usual care.