Marfan syndrome was associated with higher proximal aorta pulse wave velocity compared to healthy volunteers (5.7 vs 4.8 m/s, P<0.004) and a greater age-related increase (7 vs 3 cm/s, P=0.03).
Case-Control (n=50)
Does velocity-encoded MRI detect differences in age-related aortic stiffness between patients with Marfan syndrome and healthy volunteers?
Velocity-encoded MRI demonstrates that patients with Marfan syndrome have significantly higher baseline aortic stiffness and more pronounced age-related stiffening in the proximal aorta compared to healthy individuals.
Absolute Event Rate: 5.7% vs 4.8%
p-value: p=<0.004
PURPOSE: To study age-related change in aortic stiffness in patients with Marfan syndrome (MFS) versus healthy volunteers using velocity-encoded (VE) MRI. MATERIALS AND METHODS: Twenty-five MFS patients (age range, 18-63 years; mean age 36 ± 14 years, 13 men) and 25 age-/gender-matched healthy volunteers were examined with VE-MRI. Aortic stiffness was expressed by pulse wave velocity (PWV), assessed in the proximal and distal part of the aorta and in the total aorta. PWV was compared between patients and volunteers and age-relation was determined by linear regression. RESULTS: PWV was significantly higher in all parts of the aorta in patients when compared with healthy volunteers (proximal aorta 5.7 ± 1.5 m/s versus 4.8 ± 0.9 m/s, distal aorta 6.4 ± 2.4 m/s versus 5.0 ± 1.2 m/s and total aorta 5.9 ± 1.7 m/s versus 4.9 ± 1.1 m/s, all P < 0.004). PWV correlated significantly with age (Pearson R between 0.45 and 0.94). Only in the proximal aorta, the increase in PWV with age was significantly higher in patients (7 ± 2 cm/s increase with age) than in volunteers (3 ± 1 cm/s increase, P = 0.03); in the distal or total aorta, the increase in PWV with age was not different between patients and volunteers. CONCLUSION: Velocity-encoded MRI detects more pronounced age-related aortic stiffening in the proximal aorta in MFS patients versus healthy volunteers, suggesting more severe wall disease in MFS.
Westenberg et al. (Thu,) conducted a case-control in Marfan syndrome (n=50). Marfan syndrome vs. Healthy volunteers was evaluated on Pulse wave velocity (PWV) in the proximal aorta (p=<0.004). Marfan syndrome was associated with higher proximal aorta pulse wave velocity compared to healthy volunteers (5.7 vs 4.8 m/s, P<0.004) and a greater age-related increase (7 vs 3 cm/s, P=0.03).
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