High-intensity exercise (≥30 min/day) or moderate-intensity exercise (≥60 min/day) significantly increased superoxide dismutase activity in the ventricular myocardium (+10-30%, P<0.05).
Does exercise training improve antioxidant enzyme activities in the ventricular myocardium in female Fischer-344 rats?
High-intensity or long-duration moderate-intensity exercise effectively upregulates superoxide dismutase activity in the ventricular myocardium of rats.
p-value: p=<0.05
Controversy exists as to the effect of endurance training on myocardial antioxidant enzyme activity. These experiments sought to clarify this issue by examining antioxidant enzyme activities in the rat ventricular myocardium in response to different intensities and durations of exercise training. Female Fischer-344 rats (120 days old) were assigned to either a sedentary control group or one of nine exercise training groups. Animals were exercised on a motorized treadmill for 10 wk; combinations of three durations (30, 60, and 90 min/day), and three levels of exercise intensity (low, moderate, and high) were studied. Exercise training did not alter (P > 0.05) citrate synthase, catalase, or glutathione peroxidase activities in the right or left ventricle. In contrast, high-intensity exercise (all durations) and moderate-intensity exercise (90 min/day) resulted in a significant increase (P or = 30 min/day) or moderate-intensity exercise of long duration (> or = 60 min/day) is effective in upregulating SOD activity in the ventricular myocardium.
Powers et al. (Wed,) reported a other. Exercise training vs. Sedentary control was evaluated on Antioxidant enzyme activities in the ventricular myocardium (superoxide dismutase, citrate synthase, catalase, glutathione peroxidase) (p=<0.05). High-intensity exercise (≥30 min/day) or moderate-intensity exercise (≥60 min/day) significantly increased superoxide dismutase activity in the ventricular myocardium (+10-30%, P<0.05).