Continuous positive airway pressure therapy for 180 days significantly improved maximal oxygen consumption (p<0.05) and heart rate recovery (p<0.001) in patients with severe obstructive sleep apnea.
Does CPAP treatment improve cardiovascular performance in patients with severe obstructive sleep apnea?
Six months of CPAP therapy significantly improves exercise capacity and cardiovascular performance parameters in patients with severe obstructive sleep apnea.
p-value: p=<0.05
Background: Obstructive sleep apnea (OSA) may lead to decreased exercise capacity. We investigated whether continuous positive airway pressure (CPAP) treatment improved cardiovascular performance in OSA patients. Methods: Forty healthy subjects (control group) and 40 severe OSA patients were recruited. The two groups were matched for age, gender, and body mass index. OSA patients were assigned to CPAP and non-CPAP treatment groups in equal numbers. All subjects underwent cardiopulmonary exercise testing (CPET) using a treadmill and an incremental protocol until symptom limitation (Day 0). CPET was repeated at Day 180 in the CPAP treatment group. Results: OSA patients had lower maximal oxygen consumption (V'O 2max ) (1666.3 451.3 vs. 1375.6 227.7 ml/min, 28.2 5.5 vs. 18.9 3.8 ml/min/kg) (p < 0.001), higher maximal V'E/V'CO 2 (p < 0.01), V'E/V'O 2 (p < 0.001), heart rate (HR) reserve (p < 0.001), and blunted HR recovery (HRR) at 1-5 min (p < 0.001) compared to controls. V'O 2max was negatively correlated with AHI (R 2 = 0.1363, p < 0.05). In the CPAP but not in non-CPAP treatment group, both V'O 2max (p < 0.05), HRR (p < 0.001), and HR reserve (p < 0.05) were improved on Day 180 compared to Day 0. Conclusion: Our study demonstrates that CPAP therapy for six months provides clinical benefits by improving cardiovascular performance.
Wuttiumporn et al. (Thu,) conducted a other in Severe Obstructive Sleep Apnea (n=80). Continuous positive airway pressure (CPAP) vs. Non-CPAP treatment was evaluated on Improvement in maximal oxygen consumption (V'O2max) at Day 180 (p=<0.05). Continuous positive airway pressure therapy for 180 days significantly improved maximal oxygen consumption (p<0.05) and heart rate recovery (p<0.001) in patients with severe obstructive sleep apnea.