Calculated intracavitary stimulus potentials correlated highly with measured potentials during LV apical pacing (0.989 ± 0.002), but accuracy decreased for nonapical pacing locations (0.873 ± 0.092).
Effect estimate: 0.989 +/- 0.002 (apical) and 0.873 +/- 0.092 (nonapical)
The objective of this paper is to test the feasibility of using a multielectrode, intracavitary probe to solve a forward problem in which measured intracavitary potentials are compared to those calculated from subendocardial potentials and left ventricular (LV) cavity geometry. Intracavitary potentials and subendocardial potentials are measured simultaneously during electrical pacing stimuli from the LV apex, LV anterior base, LV posterior base, and right ventricular (RV) outflow tract of three exposed dog hearts. The LV cavity geometry is measured from postmortem magnetic resonance microscopy images of fixed hearts. Boundary integrals are approximated using a boundary element method and solved for intracavitary potentials. Correlation coefficients for LV apical pacing episodes are 0.989 +/- 0.002 while those for nonapical pacing episodes are 0.873 +/- 0.092. These results indicate that for electrical pacing from the apex, intracavitary stimulus potentials can be calculated with a high degree of accuracy. For nonapical pacing locations, the accuracy decreases since the calculations are more sensitive to errors in measuring probe position and LV cavity geometry near the septum. These results show that accurate geometric measurements of the intracavitary probe position and subendocardial surface are the primary concerns in solving future forward and inverse problems using an intracavitary probe.
Derfus et al. (Wed,) reported a other. Multielectrode intracavitary probe vs. Calculated potentials was evaluated on Correlation coefficients between measured and calculated intracavitary potentials (0.989 +/- 0.002 (apical) and 0.873 +/- 0.092 (nonapical)). Calculated intracavitary stimulus potentials correlated highly with measured potentials during LV apical pacing (0.989 ± 0.002), but accuracy decreased for nonapical pacing locations (0.873 ± 0.092).