Middle-tertile arterial stiffness (baPWV) was significantly associated with higher odds of lacunar infarcts compared to the lowest tertile (OR 2.37; 95% CI 1.10-5.11).
Cross-Sectional (n=363)
Does increased arterial stiffness associate with silent cerebrovascular lesions in individuals without symptomatic cerebrovascular disease?
Increased arterial stiffness, measured by baPWV, is independently associated with the presence of silent cerebrovascular lesions such as lacunar infarcts and white matter hyperintensities.
Odds Ratio: 2.37 (95% CI 1.1–5.11)
BACKGROUND: Arterial stiffness is a risk factor for symptomatic stroke, and is associated with symptomatic cerebral infarction and cognitive impairment. Hence, we hypothesized that arterial stiffness would be a significant determinant of silent cerebrovascular lesions. METHODS: The subjects were 363 individuals without symptomatic cerebrovascular lesions who had their arterial stiffness assessed by brachial-ankle pulse wave velocity (baPWV) measurement. The subjects were classified into two groups by the presence or absence of lacunar infarcts, as well as into three groups by grade of white matter hyperintensity (WMH). baPWV was compared among these groups. RESULTS: Eighty-six subjects had lacunar infarcts. Of 138 subjects with WMHs, 102 were classified as having grade 1 and 36 as having grade 2 or 3 WMHs. baPWV was significantly higher in subjects with lacunar infarcts than in those without (17.3 ± 0.3 vs. 16.4 ± 0.2 m/s). baPWV tended to increase with higher WMH grade (16.2 ± 0.2, 16.9 ± 0.3, and 17.8 ± 0.5 m/s in grade 0, 1, and 2 or 3, respectively) after adjustments for confounding factors. The adjusted odds ratio (OR) for lacunar infarcts in subjects with middle-tertile baPWV was significantly higher (OR, 2.37; 95% confidence interval, CI, 1.10-5.11) and the OR in subjects with the highest-tertile baPWV tended to be higher (OR 2.26; 95% CI 0.99-5.45) compared with the lowest-tertile baPWV. The adjusted OR for WMH tended to increase with increased baPWV. CONCLUSIONS: Arterial stiffness appeared to be associated with the presence of a lacunar infarct and WMH, independently of the risks for other cerebrovascular diseases.
Hatanaka et al. (토요일) 는 무증상 뇌혈관 병변(n=363)에서 단면 연구를 수행했습니다. 동맥 경직(중간 3분위수 baPWV) 대 최저 3분위수 baPWV는 내재적 경색의 존재와 평가되었습니다(OR 2.37, 95% CI 1.10-5.11). 중간 3분위수 동맥 경직(baPWV)은 최저 3분위수에 비해 내재적 경색의 높은 오즈와 유의미하게 연관되어 있었습니다(OR 2.37; 95% CI 1.10-5.11).